NGB Complex

(Neurogenesis complex)

NGB complex

Neurogenesis complex contain:

•       BAS

• THIAMINE(B1)

•        RIBOFLAVIN (B2)

•        NICOTINAMIDE (B3)

•        PANTHENOL (B5)

•        PYRIDOXAL PHOSPHATE/ P5P (B6)

•        FOLINIC ACID

•        MAGNESIUM

•        METHYLCOBALAMIN (B12)

•        HYDOXOCOBALAMIN (B12)

•        N-ACETYLCYSTEINE (NAC)

•        STERILE WATER

MAY ASSIST THE FOLLOWING:

•        Production and metabolism of cellular energy

•        Metabolism of carbohydrates, fats and proteins

•        Nervous system function

•        Immune system function

Higher dose of B vitamins, peptides, minerals in an easy to dispense format.

A Comprehensive blend of B vitamins, folinic acid, BAS, NAC, and Magnesium

Featuring activated forms of B6, and B12, this formula has been created to meet the needs of patients with methylation polymorphisms.

B vitamins are important nutrients that are involved in hundreds of metabolic and enzymatic reactions. A deficiency in B vitamins can impact nutrient metabolism, protein metabolism, the synthesis of neurotransmitters and other amino acids and proteins, fertility and pregnancy, immunity, antioxidant capabilities, energy production and they play an important role in one-carbon metabolism serving as cofactor enzymes.

B vitamins have traditionally been taken together for their synergistic role in supporting various systems of the body.

Support energy levels via providing important nutritional coenzymes required in the Krebs cycle, glycolysis and other biochemical pathways.

Support cardiovascular health via regulating the homeostasis of methylation

Support healthy immunity via assisting with the quenching of free radicals (antioxidants) and in DNA repair (methylation)

Provides neurological support through efficient methylation and the synthesis of essential proteins (myelin sheath) as cofactors in metabolic processes.

Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in maintaining good health. Here are some of the health benefits may be associated with thiamine:

•         Energy Metabolism: Thiamine is a coenzyme involved in the metabolism of carbohydrates. It helps convert glucose into energy, which is essential for the proper functioning of organs, tissues, and cells.

•         Nervous System Function: Thiamine is vital for the health of the nervous system. It plays a key role in the transmission of nerve signals and helps maintain the integrity of nerve cells.

•         Cardiovascular Health: Thiamine contributes to the health of the cardiovascular system by supporting the proper functioning of the heart. It helps in the production of ATP (adenosine triphosphate), the energy currency of cells, including those in the heart.

•         Muscle Function: Thiamine is important for muscle function and helps in the contraction of muscles. It is particularly crucial for the heart muscle.

•         Brain Function: Adequate levels of thiamine are essential for optimal brain function. Thiamine deficiency can lead to cognitive impairment, memory problems, and other neurological issues.

•         Digestive Health: Thiamine plays a role in the production of stomach acid, which is important for the digestion of food. It also helps in maintaining a healthy appetite.

•         Supports the Immune System: Thiamine is involved in the production of lymphocytes, a type of white blood cell that plays a crucial role in the immune system. Adequate thiamine levels support overall immune function.

•         Antioxidant Activity: Thiamine has antioxidant properties, helping to neutralize free radicals in the body. This may contribute to overall cellular health and reduce oxidative stress.

•         Mood Regulation: Thiamine is involved in the synthesis of neurotransmitters, including serotonin. Adequate thiamine levels may contribute to a stable mood and overall mental well-being.

•         Maintenance of Vision: Thiamine is important for maintaining eye health, and a deficiency can contribute to issues such as dry eyes and visual disturbances.

Riboflavin, also known as vitamin B2, is a water-soluble vitamin that plays a crucial role in various physiological processes in the body. Here are some of the health benefits may be associated with riboflavin:

•         Energy Metabolism: Riboflavin is a key component of two coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), both of which are involved in the metabolism of carbohydrates, proteins, and fats. They play a crucial role in the production of energy (ATP) from these macronutrients.

•         Cell Growth and Development: Riboflavin is essential for normal cell growth and development. It is particularly important during periods of rapid growth, such as infancy, adolescence, and pregnancy.

•         Eye Health: Riboflavin is important for maintaining healthy eyes. It contributes to the formation of essential enzymes involved in the prevention of conditions like cataracts and maintains good vision.

•         Skin Health: Riboflavin is involved in the maintenance of healthy skin, nails, and hair. It helps in the production of collagen, a protein that provides structure to the skin.

•         Antioxidant Activity: Like other B-vitamins, riboflavin has antioxidant properties. It helps neutralize free radicals in the body, protecting cells from oxidative stress and potential damage.

•         Nervous System Support: Riboflavin is involved in the production of neurotransmitters, the chemical messengers that transmit signals between nerve cells. Adequate levels of riboflavin contribute to the proper functioning of the nervous system.

•         Red Blood Cell Formation: Riboflavin plays a role in the formation of red blood cells (erythrocytes). It is involved in the synthesis of the molecule heme, which is a component of hemoglobin, the oxygen-carrying protein in red blood cells.

•         Migraine Prevention: Some studies suggest that riboflavin supplementation may help reduce the frequency and severity of migraines. However, more research is needed to establish a clear link.

•         Cancer Prevention: Riboflavin, along with other B-vitamins, is being studied for its potential role in preventing certain types of cancer. However, more research is needed to confirm these associations.

Nicotinamide, also known as vitamin B3 or niacinamide, is a water-soluble vitamin that offers several health benefits. Here are some of the key health benefits may be associated with nicotinamide:

•         Energy Metabolism: Nicotinamide is a precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), coenzymes involved in various metabolic processes. These coenzymes play a crucial role in the breakdown of carbohydrates, fats, and proteins to produce energy.

•         DNA Repair and Integrity: Nicotinamide is involved in DNA repair mechanisms, helping to maintain the integrity of the genetic material within cells. This function is essential for preventing mutations and supporting overall cell health.

•         Skin Health: Nicotinamide has been shown to have positive effects on skin health. It may help improve the appearance of aging skin by promoting collagen production, reducing hyperpigmentation, and providing anti-inflammatory effects. It is often included in skincare products for its potential to support skin function.

•         Neurological Health: Nicotinamide plays a role in supporting the health of the nervous system. It has been studied for its potential neuroprotective effects and its ability to support cognitive function.

•         Cardiovascular Health: Nicotinamide is associated with cardiovascular benefits. It may help in maintaining healthy cholesterol levels, reducing inflammation, and improving blood vessel function, which contributes to overall cardiovascular well-being.

•         Immune System Support: Nicotinamide is involved in immune system function. It helps support the production of immune cells and contributes to the proper functioning of the immune response.

•         Mood Regulation: Some studies suggest a potential link between nicotinamide levels and mood regulation. Adequate nicotinamide may have a positive impact on mental well-being, although more research is needed to fully understand this connection.

•         Prevention of Pellagra: Pellagra is a condition caused by severe niacin deficiency. Nicotinamide, as a form of niacin, helps prevent and treat pellagra, which is characterized by symptoms such as dermatitis, diarrhea, and dementia.

•         Osteoarthritis: There is some evidence to suggest that nicotinamide may have a protective effect against the progression of osteoarthritis. It may help preserve joint structure and function.

 Pantothenol, also known as vitamin B5, is a water-soluble vitamin that is part of the B-vitamin complex. Panthenol is the alcohol analog of pantothenic acid, the biologically active form of vitamin B5. Here are some of the potential benefits associated with panthenol:

•         Skin Health: Panthenol is widely used in skincare products for its moisturizing properties. When applied topically, panthenol is converted to pantothenic acid, which is a component of coenzyme A. This conversion is believed to contribute to improved skin hydration and softness. Panthenol is often found in creams, lotions, and ointments designed to soothe and moisturize the skin.

•         Wound Healing: Panthenol is known for its role in promoting wound healing. It is believed to accelerate the healing process by supporting the formation of new tissues. This property makes it a common ingredient in ointments and creams used to treat minor cuts, burns, and other skin irritations.

•         Hair Health: Panthenol is often included in hair care products, such as shampoos and conditioners, for its conditioning and moisturizing effects. It can help improve the texture of hair, making it smoother and more manageable. Additionally, panthenol is believed to strengthen hair and reduce split ends.

•         Anti-Inflammatory Properties: Panthenol is thought to have mild anti-inflammatory effects, making it beneficial for soothing irritated or inflamed skin. It can be used in formulations aimed at calming conditions like sunburns or mild dermatitis.

•         Nail Health: Panthenol is sometimes included in nail care products for its moisturizing properties. It may help strengthen nails and prevent them from becoming brittle.

•         Improves Skin Barrier Function: Panthenol is thought to support the skin's natural barrier function. By enhancing the moisture-retaining capacity of the skin, it helps protect against environmental factors that can lead to dryness and irritation.

•         Reduces Itching and Redness: Panthenol's soothing properties can help alleviate itching and redness associated with various skin conditions. It is often found in formulations designed to relieve discomfort caused by dry or irritated skin.

•         Hydration for Mucous Membranes: Panthenol's moisturizing properties extend to mucous membranes. It can be included in formulations for lip care or eye drops to provide hydration and promote comfort.

P5P (Pyridoxal-Phosphate), also known as vitamin B6, is a water-soluble vitamin that plays a crucial role in various physiological processes in the body. Here are some of the key health benefits may be associated with pyridoxal phosphate:

•         Metabolism of Amino Acids: Pyridoxal phosphate is involved in the metabolism of amino acids, the building blocks of proteins. It acts as a coenzyme in the conversion of amino acids, facilitating the synthesis of proteins and other important molecules.

•         Neurotransmitter Production: Pyridoxal phosphate is essential for the synthesis of neurotransmitters, such as serotonin, dopamine, and gamma-aminobutyric acid (GABA). These neurotransmitters play a crucial role in mood regulation, sleep, and overall cognitive function.

•         Hemoglobin Formation: Pyridoxal phosphate is involved in the synthesis of hemoglobin, the protein responsible for transporting oxygen in red blood cells. Adequate levels of vitamin B6 contribute to the proper formation of hemoglobin.

•         Immune System Support: Vitamin B6 is important for the proper functioning of the immune system. It helps in the production of immune cells and antibodies, contributing to the body's defense against infections and diseases.

•         Homocysteine Regulation: Pyridoxal phosphate, along with other B-vitamins, helps regulate the levels of homocysteine, an amino acid associated with an increased risk of cardiovascular disease when elevated. Adequate B6 intake may help maintain optimal homocysteine levels.

•         Pregnancy Support: Vitamin B6 is crucial during pregnancy for fetal brain development and the formation of the nervous system. It may also help alleviate symptoms of nausea and vomiting (morning sickness) during pregnancy.

•         Reduction of Inflammation: Pyridoxal phosphate has anti-inflammatory properties and may help reduce inflammation in the body. This can be beneficial in conditions where inflammation plays a role, such as rheumatoid arthritis.

•         Cognitive Function: Adequate levels of vitamin B6 are important for maintaining cognitive function and preventing age-related cognitive decline. It supports the health of the nervous system and may contribute to optimal brain function.

•         Regulation of Hormones: Vitamin B6 is involved in the synthesis and metabolism of various hormones, including those involved in the regulation of mood, sleep, and the menstrual cycle.

•         Skin Health: Pyridoxal phosphate plays a role in skin health by contributing to the formation of collagen, the protein responsible for the structure and elasticity of the skin.

Vitamin B9, also known as folate or folic acid, is a water-soluble vitamin that plays a crucial role in various bodily functions. Here are some key benefits may be associated with vitamin B9:

·       Cell Division and DNA Synthesis: Folate is essential for cell division and the synthesis of DNA, RNA, and proteins. This is particularly important during periods of rapid cell growth, such as pregnancy and infancy.

·       Prevention of Neural Tube Defects: Adequate intake of vitamin B9 before and during early pregnancy is crucial for preventing neural tube defects in the developing fetus. Neural tube defects affect the brain and spinal cord.

·       Red Blood Cell Formation: Vitamin B9 is involved in the production and maturation of red blood cells. It helps prevent anemia by supporting the synthesis of hemoglobin.

·       Cardiovascular Health: Folate plays a role in maintaining cardiovascular health by helping to regulate homocysteine levels. Elevated homocysteine levels are associated with an increased risk of cardiovascular diseases.

·       Mental Health and Cognitive Function: Some studies suggest that adequate levels of folate may contribute to mental health and cognitive function. Low folate levels have been linked to an increased risk of depression and cognitive decline.

·       Prevention of Certain Cancers: Folate may play a role in reducing the risk of certain cancers, such as colorectal cancer. However, more research is needed to fully understand the relationship between folate and cancer prevention.

·       Supports Immune System: Folate is involved in the production and maturation of immune cells, contributing to a well-functioning immune system.

·       Methylation Reactions: Folate is a key player in methylation reactions, which are essential for various biochemical processes in the body. Methylation is crucial for the regulation of gene expression and the metabolism of neurotransmitters.

·       Eye Health: Some studies suggest that folate, along with other nutrients like vitamins B6 and B12, may help reduce the risk of age-related macular degeneration (AMD), a common cause of vision loss in older adults.

Magnesium is an essential mineral that plays a crucial role in numerous physiological functions within the body.  Magnesium plays a role in methylation processes within the body, contributing to various biochemical reactions that involve the transfer of methyl groups. Methylation is a crucial biological process that involves the addition of a methyl group (a carbon atom bonded to three hydrogen atoms) to a molecule. This process is involved in numerous essential functions, including DNA and RNA synthesis, neurotransmitter production, detoxification, and more.

Here are some key health benefits associated with magnesium:

·       Muscle Function: Magnesium is vital for proper muscle function, including muscle contraction and relaxation. It plays a role in the regulation of neuromuscular signals.

·       Bone Health: Magnesium is an important component of bone health, working alongside calcium and vitamin D to support bone structure and density. It is involved in bone mineralization.

·       Energy Production: Magnesium is a cofactor for enzymes involved in the production of adenosine triphosphate (ATP), the primary energy currency of cells. It plays a crucial role in cellular energy metabolism.

·       Heart Health: Magnesium is associated with cardiovascular health. It helps regulate blood pressure, supports the function of the heart muscle, and may contribute to the prevention of heart rhythm disturbances.

·       Nervous System Function: Magnesium is involved in the regulation of neurotransmitters and plays a role in nerve function. It may contribute to the prevention of conditions like migraines and help with stress management.

·       Blood Sugar Regulation: Magnesium plays a role in insulin sensitivity and glucose metabolism. Adequate magnesium levels may contribute to better blood sugar control and a reduced risk of type 2 diabetes.

·       Support for Sleep: Magnesium is sometimes associated with improved sleep quality. It may help relax muscles and regulate neurotransmitters involved in sleep.

·       Anti-Inflammatory Properties: Magnesium has been suggested to have anti-inflammatory effects, potentially contributing to the prevention or management of chronic inflammatory conditions.

·       Regulation of Calcium Levels: Magnesium helps regulate calcium levels in the body. Proper balance between magnesium and calcium is important for various physiological processes, including muscle contraction and nerve function.

·       Mood and Mental Health: Some research suggests a link between magnesium levels and mood. Magnesium may have a role in the regulation of neurotransmitters associated with mood and stress.

·       Cofactor for Enzymes: Magnesium serves as a cofactor for various enzymes involved in methylation reactions. These enzymes facilitate the transfer of methyl groups, playing a role in processes like the conversion of homocysteine to methionine.

·       Methionine Synthesis: Magnesium is involved in the conversion of homocysteine to methionine, a critical step in the methylation cycle. This process is important for the synthesis of S-adenosylmethionine (SAMe), a methyl donor involved in many methylation reactions.

·       DNA and RNA Methylation: Methylation is crucial for the regulation of gene expression, and magnesium plays a role in the methylation of DNA and RNA. This process is essential for the proper functioning and regulation of genes.

·       Neurotransmitter Synthesis: Magnesium contributes to the synthesis of neurotransmitters, including dopamine and serotonin, through methylation processes. These neurotransmitters play a crucial role in mood regulation, among other functions.

·       Detoxification: Methylation is involved in the detoxification of various substances in the body, including certain drugs and environmental toxins. Magnesium supports these detoxification processes by serving as a cofactor for relevant enzymes.

·       Energy Metabolism: Magnesium is involved in the activation of enzymes that participate in energy metabolism. This includes methylation reactions related to the metabolism of amino acids and the production of ATP (adenosine triphosphate).

·       Cardiovascular Health: Proper methylation, facilitated in part by magnesium, contributes to cardiovascular health by helping to regulate homocysteine levels. Elevated homocysteine is associated with an increased risk of cardiovascular diseases.

N-acetylcysteine (NAC) is a form of the amino acid cysteine. Cysteine is a building block of the antioxidant glutathione, which plays a crucial role in various physiological processes in the body. NAC can replenish glutathione levels and may have a diverse range of potential health benefits.

NAC is available in both prescription and over-the-counter forms. In medical settings, it is sometimes used as a medication, particularly in cases of acetaminophen (paracetamol) overdose, as it can help prevent or reduce liver damage by replenishing glutathione.

Outside of medical applications, NAC is commonly used as a dietary supplement and is available in capsule, tablet, or powder form. It has gained attention for its antioxidant properties, mucolytic effects. Here are some of the key health benefits associated with NAC:

·       Antioxidant Support: NAC is a precursor to the amino acid cysteine, which is essential for the synthesis of glutathione, a powerful antioxidant in the body. Glutathione helps neutralize free radicals and oxidative stress, contributing to overall cellular health.

·       Liver Health: NAC is used medically to treat acetaminophen (paracetamol) overdose, as it replenishes glutathione levels in the liver and helps prevent or reduce liver damage. It may also support liver function in various conditions.

·       Respiratory Health: NAC has mucolytic properties, meaning it can break down and thin mucus. It is commonly used to assist in respiratory conditions such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis.

·       Detoxification: Due to its role in promoting glutathione production, NAC is believed to assist in detoxifying the body by aiding in the elimination of harmful substances, including environmental toxins and heavy metals.

·       Mental Health: Some studies suggest that NAC may have positive effects on mental health. It has been investigated as a potential adjunctive treatment for conditions such as depression, bipolar disorder, and obsessive-compulsive disorder (OCD).

·       Antidepressant Effects: NAC has been studied for its potential antidepressant effects, and it may influence neurotransmitter systems in the brain, including glutamate modulation.

·       Cognitive Function: Research indicates that NAC may have neuroprotective effects and could be beneficial for cognitive function. It has been explored for its potential role in conditions like Alzheimer's disease and mild cognitive impairment.

·       Immune System Support: NAC may have immune-modulating properties, and some studies suggest that it could enhance the immune system's response to infections and diseases.

·       Anti-Inflammatory Effects: NAC has anti-inflammatory properties, and inflammation is often associated with pain. By reducing inflammation, NAC may contribute to alleviating pain associated with inflammatory conditions.

·       Oxidative Stress Reduction: NAC is a precursor to glutathione, a potent antioxidant. Oxidative stress can contribute to various health issues, including pain. By increasing glutathione levels, NAC may help reduce oxidative stress and its potential contribution to pain.

·       Neuropathic Pain: Some studies have explored the potential role of NAC in managing neuropathic pain, which is pain caused by damage or dysfunction of the nervous system. NAC's antioxidant and anti-inflammatory properties may be relevant in this context.

Methylcobalamin is one of the active forms of vitamin B12 (cobalamin), which is a water-soluble vitamin that plays a crucial role in various bodily functions. Vitamin B12 is essential for the formation of red blood cells, neurological function, and the synthesis of DNA. Methylcobalamin is a biologically active form of vitamin B12 that is readily utilized by the body. Here are some potential benefits may be associated with methylcobalamin:

·       Energy Metabolism: Vitamin B12, including its methylcobalamin form, plays a crucial role in energy metabolism. It is involved in the conversion of food into energy, helping to maintain the proper functioning of cells and tissues.

·       Nervous System Support: Methylcobalamin is essential for the health of the nervous system. It is involved in the production of myelin, a protective sheath that surrounds nerve fibers, promoting nerve function and communication.

·       Cognitive Function: Adequate levels of vitamin B12, including methylcobalamin, are important for cognitive function and may play a role in preventing cognitive decline and supporting memory.

·       Red Blood Cell Formation: Methylcobalamin is involved in the formation of red blood cells. It works with other B vitamins to support the production of hemoglobin, the oxygen-carrying component of red blood cells.

·       Homocysteine Regulation: Vitamin B12 helps regulate homocysteine levels in the blood. Elevated homocysteine levels are associated with an increased risk of cardiovascular disease, and adequate vitamin B12 intake, including methylcobalamin, may help lower these levels.

·       Mood and Mental Health: There is some evidence suggesting a link between vitamin B12 levels, including methylcobalamin, and mood. Deficiency in vitamin B12 has been associated with symptoms such as depression and anxiety.

·       DNA Synthesis and Repair: Methylcobalamin is involved in the synthesis and repair of DNA. It plays a role in cell division and the maintenance of genetic material.

·       Eye Health: Vitamin B12, along with other B vitamins, is important for maintaining healthy vision. It may help reduce the risk of age-related macular degeneration (AMD), a common cause of vision loss in older adults.

·       Support for Vegetarians and Vegans: Methylcobalamin is a common form of vitamin B12 used in supplements, and it is particularly important for individuals following a vegetarian or vegan diet, as vitamin B12 is mainly found in animal products.

·       Vitamin B12, including methylcobalamin, is crucial for cognitive function. It plays a role in the synthesis of neurotransmitters, including serotonin and dopamine, which are essential for mood regulation, focus, and memory.

·       Memory Support: Adequate levels of vitamin B12 are associated with better memory performance. Deficiency in B12 has been linked to memory impairment and cognitive decline, especially in older adults.

·       Nervous System Health: Methylcobalamin is essential for the health of the nervous system. It is involved in the formation of myelin, the protective sheath around nerve fibers, facilitating nerve signal transmission and maintaining nerve function.

·       Prevention of Cognitive Decline: Some research suggests that sufficient vitamin B12 levels, including methylcobalamin, may play a role in preventing age-related cognitive decline and reducing the risk of neurodegenerative diseases such as Alzheimer's.

·       Mood Regulation: Vitamin B12 is involved in the synthesis of neurotransmitters that play a role in mood regulation. Deficiency in B12 has been associated with symptoms such as depression and anxiety.

·       Support for Mental Health Disorders: There is ongoing research exploring the potential role of vitamin B12, including methylcobalamin, in supporting mental health disorders such as depression and bipolar disorder.

·       Homocysteine Regulation: Methylcobalamin is involved in the conversion of homocysteine to methionine. Elevated homocysteine levels are associated with an increased risk of cardiovascular disease and may also have implications for cognitive health.

·       Energy Production in Brain Cells: Vitamin B12, as part of the B-vitamin complex, is involved in the production of energy in brain cells. This energy is essential for various cellular processes, including neurotransmitter synthesis and signaling.

Hydroxocobalamin, a form of vitamin B12, may play a crucial role in several physiological processes in the body. Here are some of the key health benefits may be associated with hydroxocobalamin:

•         “Neural Detoxifier” 🧠

•         Red Blood Cell Formation: Vitamin B12, including its hydroxocobalamin form, is essential for the production of red blood cells. It is a key component in the synthesis of hemoglobin, the protein responsible for carrying oxygen in the blood.

•         Neurological Function: Vitamin B12 is crucial for maintaining the health of the nervous system. It plays a role in the formation of myelin, the protective covering of nerve fibers. Deficiencies in B12 can lead to neurological issues, including numbness, tingling, and difficulty with balance and coordination.

•         Energy Metabolism: Hydroxocobalamin is involved in the metabolism of fats and proteins, contributing to the production of energy. It works as a cofactor in several enzymatic reactions that are part of the energy-generating processes in cells.

•         DNA Synthesis: Vitamin B12 is necessary for DNA synthesis and cell division. It plays a role in the synthesis of nucleotides, the building blocks of DNA, and helps maintain the integrity of genetic material.

•         Homocysteine Regulation: Vitamin B12, along with other B-vitamins, helps regulate homocysteine levels in the blood. Elevated homocysteine is associated with an increased risk of cardiovascular disease, and adequate B12 intake may help maintain optimal levels.

•         Cognitive Function: Vitamin B12 is important for cognitive function, and deficiency has been linked to cognitive decline and an increased risk of neurological disorders, including dementia.

•         Mood Regulation: Some studies suggest a link between vitamin B12 status and mood regulation. B12 is involved in the synthesis of neurotransmitters such as serotonin, which plays a role in mood and emotional well-being.

•         Supports Immune System: Vitamin B12 supports the immune system by participating in the production and maturation of immune cells. Adequate B12 levels contribute to a healthy and responsive immune system.

•         Folate Metabolism: Vitamin B12 works in conjunction with folate (vitamin B9) to metabolize folate. This interaction is important for various processes, including DNA synthesis and red blood cell formation.

•         Bone Health: Some research suggests that vitamin B12 may play a role in bone health, although the mechanisms are not fully understood. Adequate B12 levels may contribute to bone density and health.

Vitamin B12, or cobalamin, comprises a family with five distinct members: cyanocobalamin, hydroxycobalamin, adenosylcobalamin, glutathionylcobalamin, and methylcobalamin (Methyl B12 or MB12). Among these, only Methyl B12 has the unique ability to directly activate the methylation biochemical pathway by donating a "methyl" group.

Think of a methyl donor as fuel for the brain. Increased delivery of this "fuel" to the brain through MB12 has shown improvements in speech, language, social, and cognitive skills in autism treatment.

MB12 and folic acid work synergistically to regulate methylation, supporting both the methylation cycle and the folate cycle. The methylation cycle, in turn, governs around two hundred essential functions in the body. Growing evidence highlights the critical role of this pathway in the interaction between environmental factors and genetic expression in autism risk and severity.

Methylation is also implicated in processes such as inflammation, impacting children's development after birth. Many developmentally delayed children experience methylation impairment, leading to potential alterations in various biochemical processes.

MB12 injections, as part of autism treatment, enhance methylation, supporting the production of cell membranes, proteins, genetic material, and regulating immune function. They also contribute to detoxification, glutathione production (the body's master antioxidant), maintenance of active forms of vitamins E and C, and reduction of inflammation.

Positive effects of MB12 injections in autism treatment include increased awareness, responsiveness, improved cognition, eye contact, social appropriateness, and reduced self-stimulatory behaviours. Undesired effects, often temporary, may include hyperactivity, self-stimulating behaviour, and sleep disturbances.

Methylation, interconnected with the folate cycle, is crucial for optimal development. Methylation impairment, if not supported by MB12 and other methyl donors, can lead to significant changes in cell function.

Furthermore, MB12 injections play a role in the production of glutathione, the body's master antioxidant, vital for detoxification. Reduced glutathione levels, as seen in autism, can lead to a buildup of toxic substances and hinder methylation.

Excess glutamate, a neurotransmitter, is managed by the brain's immune cells through proper methylation. MB12 injections help reduce excess glutamate, mitigating issues related to immunoexcitotoxicity and improving outcomes in autism treatment.

MB12 injections positively impact autism treatment by supporting methylation, enhancing serotonin and dopamine production, reducing glutamate, and improving sensory-related behaviors. Understanding the intricate relationship between methylation, neurotransmitters, and detoxification sheds light on the developmental gains observed in children undergoing this biomedical intervention.

Excitotoxicity is a pathological process that occurs in the nervous system when nerve cells (neurons) are damaged and killed by excessive stimulation by neurotransmitters, particularly glutamate. Glutamate is the primary excitatory neurotransmitter in the brain and plays a crucial role in normal neuronal function. However, when there is an abnormal increase in glutamate levels or impaired regulation, it can lead to excitotoxicity.

Key components of excitotoxicity:

Glutamate Release: Glutamate is released by neurons into the synapses, the small gaps between nerve cells where communication takes place. It acts as a chemical messenger, transmitting signals between neurons.

Receptor Activation: Glutamate binds to specific receptors on the surface of neighbouring neurons, particularly N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. When these receptors are activated, they allow the influx of calcium ions into the neuron.

Intracellular Calcium Overload: Excessive activation of NMDA and AMPA receptors leads to an influx of calcium ions into the neuron. Intracellular calcium overload can trigger a cascade of events, including the activation of enzymes that damage cell structures and mitochondria, ultimately leading to cell death.

Cellular Damage and Death: The excessive influx of calcium and the subsequent activation of destructive enzymes can cause damage to cellular structures, DNA, and other components. This damage may lead to the death of the neuron, a process known as excitotoxic cell death.

Excitotoxicity is implicated in various neurological conditions and injuries, including:

Stroke: Lack of blood flow to the brain during a stroke can lead to the release of large amounts of glutamate, contributing to excitotoxic damage to neurons.

Traumatic Brain Injury (TBI): Trauma to the brain can result in the release of glutamate, leading to excitotoxicity and secondary brain damage.

Neurodegenerative Diseases: Conditions like Alzheimer's, Parkinson's, and Huntington's diseases involve excitotoxicity as a contributing factor to the progressive loss of neurons.

Seizures: Excessive and prolonged seizures can result in increased glutamate release and excitotoxic damage to neurons.

Ischemia: Conditions involving reduced blood flow to the brain, such as cardiac arrest or certain types of vascular disorders, can trigger excitotoxicity.

Excitotoxicity is a phenomenon where nerve cells (neurons) are damaged and killed by excessive stimulation by neurotransmitters, particularly glutamate. Vitamin B, specifically certain B-vitamins, can play a role in mitigating excitotoxicity through various mechanisms:

Vitamin B6 (Pyridoxal phosphate): Vitamin B6 is a co-factor in the synthesis of neurotransmitters, including serotonin, dopamine, and gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter that counteracts the effects of excitatory neurotransmitters like glutamate. By supporting GABA synthesis, vitamin B6 indirectly helps balance the excitatory and inhibitory activities in the brain.

Vitamin B9 (Folate): Folate, also known as vitamin B9, is involved in the synthesis and regulation of neurotransmitters, including serotonin and dopamine. Adequate levels of folate are essential for maintaining proper neurotransmitter balance, which contributes to normal brain function and may help prevent excessive excitatory signals.

Vitamin B12 (Cobalamin): Vitamin B12 plays a role in the synthesis of myelin, the protective sheath around nerve fibers. This can indirectly contribute to maintaining the health of neurons and preventing excessive stimulation. Additionally, vitamin B12 is involved in the methylation cycle, which influences the regulation of neurotransmitters and may help modulate excitatory processes.

Vitamin B3 (Niacin): Niacin is a precursor to nicotinamide adenine dinucleotide (NAD), which plays a role in energy metabolism. Proper energy metabolism is crucial for maintaining the balance of neurotransmitters and preventing excitotoxicity.

Vitamin B5 (Pantothenic Acid): Pantothenic acid is a component of coenzyme A, which is involved in various metabolic pathways, including the production of neurotransmitters. By supporting these processes, vitamin B5 indirectly contributes to the regulation of excitatory signals.

Vitamin B1 (Thiamine): Thiamine is essential for proper nerve function and energy metabolism. Thiamine deficiency can lead to neurological symptoms, including increased sensitivity to excitotoxicity. Ensuring adequate thiamine levels can help maintain normal nerve function and prevent excessive excitatory signalling.

B-vitamins are essential for overall neurological health and can indirectly influence processes related to excitotoxicity.

BAS contains the following:

OCH : - oligocarbohydrates, that is carbohydrates within components with a molecular mass

M=800÷10,000 Da;

PCH : - polycarbohydrates, that is the carbohydrates within components with a molecular mass M>10,000 Da;

MCH : - monocarbohydrates, that is carbohydrates in the form of monomers or components with a molecular mass M<800 Da;

PP : - polypeptides with a molecular mass M>10,000 Da;

P : - Assortment of peptides with a molecular mass M<10,000 Da;

AMA : - free amino acids;

GL : - glycolipids;

L : - lipides;

N : - nucleotides.

BAS has a wide spectrum of abilities for their use in veterinary and medicine and may help in normalization of physiological state of the organism in treatment of diseases, controlled by the immune system. The administration of BAS affords stimulation of: functional activity of liver tissue in hepatitis; regeneration of liver after hepatectomy; healing of ulcers, wounds, cutaneous surface in wounds and damages; treatment of inflammatory diseases (mastitis, pneumonias, endometritis); treatment of infectious diseases (parainfluenza, ARD); help increasing of the animal resistance to infectious and inflammatory processes; improvement of general biological state of the organism; help rise of additional weight increase of animals.