BASE GEL The Base Gel of Mast Calm is a key component and is essential to getting active ingredients where you need it. Our Transdermal case is an organic gel made from lecithin.

It has been formulated to have cosmetic properties, being non-greasy and having improved skin penetration of incorporated active ingredients. After application to the skin, it rapidly disappears leaving no residue. It has been widely accepted as a superior vehicle for delivering product across the skin barrier where high local concentrations of ingredients are obtained from small, applied doses. It also allows these ingredients to penetrate the skin reaching the general circulation when desired, making the topical route possible.

SYNERGISTICS

In addition to our organic antihistamine, we have also added 99% pure Quercetin and CNS Bio-peptide regulators which have synergistic effects when combined.

QUERCETIN

Research suggests that quercetin can be used as an effective antihistamine, as it restricts mast cell histamine from being released from cells.

Inflammation is the body’s natural response to stress and injuries and usually helps the body heal. However, chronic inflammation can be harmful to the body and may contribute to certain health conditions, quercetin can reduce inflammation.

Quercetin has several effects in many organs including brain, blood vessels, muscle, intestine, liver, kidney, skin, and bone, and influences neurodegenerative diseases, mood disorders, atherosclerosis, and metabolic syndrome, where mast cells are likely involved. In addition, quercetin treatments of neurodegenerative diseases cause modulation of proinflammatory and anti-inflammatory cytokines and chemokines. The flavonoid quercetin has a variety of functions including the inhibition of histamine release from human basophils and murine mast cells. Moreover, quercetin is a potent anticytokine and chemokine generated from several cell types, which has an inhibitor effect in immunological and non-immunological conditions, mediated by mast cells. It has been reported that quercetin inhibits, in a dose-response manner, tryptase and MCP-1. In addition, using RT-PCR, quercetin inhibits the transcription of histidine decarboxylase, the enzyme responsible for the generation of histamine from histidine. This data suggest that quercetin is a good candidate for reducing the release of pro-inflammatory mast cell mediators. Quercetin inhibits contact dermatitis and photosensitivity in humans and suppresses ultraviolet irradiation-induced expression of inflammatory cytokines IL-1β, IL-6, IL8 and TNF in human keratinocytes.

CNS BIO PEPTIDE REGULATORS

Peptides are small data molecules, short chains of amino acids, the address coordinates of genes. Peptides are formed in the cells of various tissues of the body during protein metabolism. Their main function is to activate the reading of the genetic information in DNA. Thus they initiate protein synthesis in cells and regulate their proper functioning. Scientists have found that deficiency of peptides in the body resulting in impaired functions in cells, cellular dysfunction, development of pathological conditions and accelerated aging of the body. At the same time, many studies have shown that the use of peptides and removal of deficiency of peptides in the body not only contributes to the regulation of cell functions but even lost cell function can be restored.

Normal functions will require nerve cells, among other things, tissue-specific peptides (peptides and nervous tissue) that support and regulate their functions. In a small number of these peptides can be ingested with food, but the main part is formed in the cells, namely the cells of the nervous tissue.

The optimal functioning of the Central nervous system of a person is directly related to the condition of nerve cells. Research shows that the health of the body depends on the health of the individual cells. If cells function well, then organs and organ systems work well. For cells to work well, they must have continuously and in sufficient quantity a supply of the necessary nutrients.

The use of peptides of the cerebral cortex is recommended to speed up the recovery of brain function after traumatic brain injury, stroke, intellectual disability disorders, effects on the body of various extreme factors. Their application also shows the elderly to maintain mental health.

• Peptides of the cerebral cortex - recommended applications

• complete functional recovery of the Central nervous system after diseases of different genesis

• pathological conditions, resulting in impaired brain function

• normalization of brain activity on the background of atherosclerosis • rehabilitation after stroke • memory loss and impaired concentration

• Alzheimer and Parkinson

• multiple sclerosis

• chronic fatigue syndrome

• depression

• neuralgia and neuritis

• the impact of extreme environmental factors

• malnutrition

• for maintaining the functional activity of the central nervous system during aging

• Areas of applications based on the biological effects of the active substances, included in this product based on scientific evidence and practical experience.

ORGANIC ANTIHISTAMINE

Our organic antihistamine is a noncompetitive H1-antihistamine and also known as a mast cell stabilizer. MAST-CALM blocks histamine receptors and stops the inflammatory effects of histamine and reduces the release of natural substances from different body immune cells that cause an allergic reaction. In Vivo: It inhibits platelet-activating factor-induced accumulation of eosinophils and platelets in the airways and suppress the mechanism of eosinophils by human recombinant cytokines then suppress the influx of eosinophils into the inflammatory site. Inhibits or antagonizes leukotrienes which cause bronchoconstriction. Also inhibits the sympathomimetic activity of the airway caused by drugs or exposure to the allergen. In Vitro: Inhibits the release of allergic mediators such as histamine, PAF, and slow release substance of anaphylaxis l(eukotrienes-C4and D4).

Mold illness:

Mold illness or mold toxicity is not an allergy but an inflammation within the body that is caused by the immune system that has gone out of control. The mold illness is a subclass of a comprehensive and multifaceted biotoxin illness called chronic inflammatory response syndrome (CIRS). The CIRS is caused by exposure to a water-damaged building which is home to a toxic mix of microbes, and harmful organisms such as fungi, mold spores, bacteria, mycobacteria, actinomycetes, inflammagens such as endotoxins, hemolysins(exotoxins), beta-glucans, mannans, proteinases, spirocyclic drimanes as well as volatile organic compounds.

Whenever people exposed to biotoxins, they become ill, but most people recover once they get rid of exposure. Their immune system recognizes the biotoxins in their bodies as toxins and removes them via the normal mechanisms.

But some people have human leukocyte antigen (HLA-DR) genes that prevent their bodies to recognize and remove biotoxins from the body. The biotoxins stay in the body and trigger a chronic, systemic inflammatory response and can lead to developing CIRS.

These biotoxins trigger mast cells that release histamine and activate other inflammatory mediators and cause headache, brain fog, memory and focusing problems, fatigue, weakness, muscle cramps, asthma, shortness of breaths, digestive issues, abdominal pain, joint pains, red eyes (conjunctivitis), numbness, tingling, tremors, vertigo, etc.

Mast-Calm may help blocking histamine receptors, stabilizes mast cells thereby stopping the allergic reactions and activation of the inflammatory mediator releasing mechanism and relieving the patients from many painful and harmful symptoms.